This course explores a range of perspectives on the role of knowledge in the economy, with a focus on introducing students to the political economy and comparative systems frameworks and using those frameworks to analyze the topic in relation to economic planning. The course has three modules: (I) Methodology and Philosophy of the Study of Economics and Knowledge, which provides a survey of the forms of knowledge and information in the economy (innovation, tacit knowledge, etc.) and introduces an array of theoretical bases for understanding knowledge and ideology. The second module, (II) Theory and Empirical Evidence of the Role of Knowledge in Economic Planning, begins with the Socialist Calculation Debates and the theme of centralized and decentralized knowledge. Building on this, we explore historical examples of knowledge in economic planning within the USSR, Yugoslavia, and the People’s Republic of China. Finally, the third module, (III) Contemporary Political Economy of Knowledge, examines knowledge under contemporary capitalism and highlights the relationship of capitalist ideology and the privatization of knowledge. This module introduces students to the so-called “knowledge-economy” and legal institutions that support knowledge-ownership (intellectual property rights). From here, the course concludes with current discussions of the monopolization and commodification of knowledge. The overarching goal of the three modules is to create a strong theoretical basis for discussion, and then explore the topic in the context of non-capitalist systems and, by contrast, under contemporary capitalism.