In the past decades, indigeneity has resurfaced as a central site of struggle in Latin America from which a variety of demands for rights and recognition are being voiced and enacted. Although indigenous resistance movements have a long history in the region, what differentiates these new demands from the past is their self-localization on a new space of contestation, situated at the intersection of indigenous local identities with their struggle for rights at a global scale. This new space is constructed through both the productive encounter and resistance of a diversity of logics, meanings, epistemologies, cosmologies, interests and power relations. Bearing this in mind, this course proposes to look at recent indigenous resistance movements in the region as privileged sites of knowledge production and resignification of the local-global connection. We will seek to bring light on the different ‘frictions’ as well as productive exchanges that make up these encounters by taking up questions of coloniality, race, gender, nature, environmental politics, international law, sovereignty and radical democracy. We will explore these and related problems through different case-studies including the Zapatistas’ Women’s Revolutionary Law in Mexico, the recognition of rights to ‘Mother Earth’ in Bolivia’s constitution, the coalition of indigenous populations and international environmental activists against extractive multinational corporations in Bolivia, Mexico, and Ecuador, the struggle for historical memory and justice by Mayan indigenous groups in Guatemala, as well as other struggles over land rights, natural resources, citizenship, autonomy and recognition across the region.