Philosophical debates often turn on the intelligibility of certain fundamental distinctions: mind/body, free/determined, universal/particular, discursive/non-discursive. This seminar will explore how recent developments in AI put pressure on several such distinctions, distinctions that have long structured both philosophical inquiry and humanistic self-understanding: human/machine, natural/artificial, intelligent/unintelligent, living/non-living. The humanities have traditionally concerned themselves with articulating what makes human experience unique and significant. We will revisit influential arguments for human distinctiveness by asking whether they retain their force in light of contemporary developments in AI. Does it still make sense to hold on to distinctions between natural and artificial, living and non-living, human and non-human?