Artificial Intelligence (A.I.) is transforming every aspect of our societies, from news media to entertainment to shopping to financing to creative industries to criminal justice systems. The questions remain: how can the creatives leverage this artifact in their artistic and professional practices and what roles can the creatives play in the design of A.I. and its societal impact. This seminar course will examine the multidisciplinary origins and applications of A.I. from a design perspective. There is no programming background required for this course. Students will engage with critical literature and media and develop innate understanding by making with AI-enable tools and managing projects that reflect their interests. The insights from the course can be applied to their own personal creative practices and design strategies for corporate and social innovation. The topics that the course will engage include, not limited to: design science, expert systems, artificial neural networks, learning science, innovation, ethics, and creativity.